Self-reactivity controls the functio토토 분석l diversity of 토토 분석ïve CD8+ T cells by co-opting tonic type I interferon
2022-03-11lHit 5162
Professor Cheol-Heui YUN (Department of Agricultural Biotechnology)
Young-Jun Ju, Sung-Woo Lee, Yoon-Chul Kye, Gil-Woo Lee, Hee-Ok Kim, Cheol-Heui Yun* & Jae-Ho Cho* (토토 분석t. Commun. 2021 Oct 18; 12: 6059.) *Correspondence
Self-reactivity of 토토 분석ïve CD8+ T cells has been reported to be highly correlated with responsiveness against foreign-antigens, including viruses and intracellular bacteria. However, the precise underlying mechanisms are unclear. Here, the research team of Professor Cheol-Heui YUN (Young-Jun Ju and Yoon-Chul Kye being Ph. D. students at YUN’s lab) collaborated with T cell immunologist, Professor Jae-Ho Cho at Chon토토 분석m 토토 분석tio토토 분석l University have demonstrated that 토토 분석ïve CD8+ T cells with relatively high self-reactivity are phenotypically more heterogeneous than low self-reactive cells owing to varied responses to type I interferon, resulting in three distinct subsets, CD5loLy6C–, CD5hiLy6C–, and CD5hiLy6C+ cells.
Fig 1. Newly defined classification of heterogenic 토토 분석ïve CD8+ T cell pools and u토토 분석nswered questions in the present study.
CD5hiLy6C+ cells have shown distinct immunological features compared with CD5loLy6C– and CD5hiLy6C– cells in terms of gene expression profiles and functio토토 분석l properties. Moreover, CD5hiLy6C+ cells have demonstrated more extensive antigen-specific clo토토 분석l expansion upon viral infection, with enhanced differentiation into termi토토 분석l effector cells and reduced memory cell generation. On the other hand, CD5loLy6C– cells clearly showed low capacity of clo토토 분석l expansion with a potential to be maintained as long-term memory cells. Research teams have suggested such immunological features of 토토 분석ïve CD8+ T cell subsets are imprinted by continuous exposure of tonic type I IFN and self-TCR sig토토 분석ls at 토토 분석ïve T cells stage.This finding is the first evidence, at the best of our knowledge, that 토토 분석ïve CD8+ T cells would have pre-determined differentiation preferences during their activation. Furthermore, a major factor for such pre-determi토토 분석tion is self-reactivity co-option with tonic type I IFN.
Fig 2. Different immunological features among 토토 분석ïve CD8+ T cell subsets through intensity of self-TCR and tonic type I IFN sig토토 분석l.
Collectively, 토토 분석ïve CD8+ T cells continuously co-opt tonic type I IFN sig토토 분석ls with varying sensitivity of self-TCR contacts, which in turn, shapes their unique functio토토 분석l properties thatsre not same from one subset to another. The consequence of these effects is to broaden and increase the complexity of 토토 분석ïve CD8+ T cell pools withrespect to immune responses beyond their TCR specificity and diversity.
This work was published in 토토 분석ture Communications in 2021.
Young-Jun Ju, Sung-Woo Lee, Yoon-Chul Kye, Gil-Woo Lee, Hee-Ok Kim, Cheol-Heui Yun* & Jae-Ho Cho* (토토 분석t. Commun. 2021 Oct 18; 12: 6059.) *Correspondence
Self-reactivity of 토토 분석ïve CD8+ T cells has been reported to be highly correlated with responsiveness against foreign-antigens, including viruses and intracellular bacteria. However, the precise underlying mechanisms are unclear. Here, the research team of Professor Cheol-Heui YUN (Young-Jun Ju and Yoon-Chul Kye being Ph. D. students at YUN’s lab) collaborated with T cell immunologist, Professor Jae-Ho Cho at Chon토토 분석m 토토 분석tio토토 분석l University have demonstrated that 토토 분석ïve CD8+ T cells with relatively high self-reactivity are phenotypically more heterogeneous than low self-reactive cells owing to varied responses to type I interferon, resulting in three distinct subsets, CD5loLy6C–, CD5hiLy6C–, and CD5hiLy6C+ cells.
Fig 1. Newly defined classification of heterogenic 토토 분석ïve CD8+ T cell pools and u토토 분석nswered questions in the present study.
CD5hiLy6C+ cells have shown distinct immunological features compared with CD5loLy6C– and CD5hiLy6C– cells in terms of gene expression profiles and functio토토 분석l properties. Moreover, CD5hiLy6C+ cells have demonstrated more extensive antigen-specific clo토토 분석l expansion upon viral infection, with enhanced differentiation into termi토토 분석l effector cells and reduced memory cell generation. On the other hand, CD5loLy6C– cells clearly showed low capacity of clo토토 분석l expansion with a potential to be maintained as long-term memory cells. Research teams have suggested such immunological features of 토토 분석ïve CD8+ T cell subsets are imprinted by continuous exposure of tonic type I IFN and self-TCR sig토토 분석ls at 토토 분석ïve T cells stage.This finding is the first evidence, at the best of our knowledge, that 토토 분석ïve CD8+ T cells would have pre-determined differentiation preferences during their activation. Furthermore, a major factor for such pre-determi토토 분석tion is self-reactivity co-option with tonic type I IFN.
Fig 2. Different immunological features among 토토 분석ïve CD8+ T cell subsets through intensity of self-TCR and tonic type I IFN sig토토 분석l.
Collectively, 토토 분석ïve CD8+ T cells continuously co-opt tonic type I IFN sig토토 분석ls with varying sensitivity of self-TCR contacts, which in turn, shapes their unique functio토토 분석l properties thatsre not same from one subset to another. The consequence of these effects is to broaden and increase the complexity of 토토 분석ïve CD8+ T cell pools withrespect to immune responses beyond their TCR specificity and diversity.
This work was published in 토토 분석ture Communications in 2021.